Qualitative Study on Disease Communication Experience between Parents and Cancer Children from the Perspective of Familism / 中国医学伦理学

【Objective:】 To explore the disease communication between cancer children and their parents from the perspective of their parents. 【Methods:】 Using qualitative description method and semi-structured interview, 16 parents from the pediatric oncology department of a tertiary A hospital were collected. Colaizzi 7-step method was used to analyze the interview data and summarize the theme. 【Results:】 Four themes were summarized, including perception of the psychological changes of children after illness, changes in the future planning of children, different attitude towards informing children’s diseases, different opinions on children’s participation in medical decision-making. 【Conclusions:】 The awareness of disease communication and medical decision-making in cancer families is insufficient. It is difficult for parents to communicate actively and effectively with their cancer children, and the children’s families are unable to make clear plans for the children’s future. Therefore, it is necessary to construct a theoretical system of disease communication and medical shared decision-making from the perspective of Chinese familism, and strengthen the promotion of scientific communication methods.

Positive psychological capital and its influencing factors among parents of children with leukemia / 四川精神卫生

BackgroundPsychological capital has a significant impact on individual post-traumatic growth and well-being. However， there is limited research on the psychological capital and its related factors among parents of children with leukemia. ObjectiveTo explore the psychological capital status of parents of children with leukemia and analyze its influencing factors， in order to provide references for formulating intervention strategies to improve the psychological capital among these parents. MethodsFrom March 2021 to April 2022， 143 parents of children diagnosed with leukemia from the Department of Pediatrics at the First Affiliated Hospital of Xinjiang Medical University was selected. The general demographic information questionnaire， Positive Psychological Capital Questionnaire （PPQ）， Chinese-Posttraumatic Growth Inventory （C-PTGI） and Index of Well-being Scale （IWB） were used to investigate the participants. Multiple linear regression analysis was used to analyze the influencing factors of psychological capital. ResultsThe PPQ total score for parents of children with leukemia was （113.48±15.80）. The PPQ total score showed positive correlations with the scores of C-PTGI and IWB （r=0.727， 0.598， P<0.01）. The course of children's illness （β=0.136， P=0.017）， parental education level （β=0.139， P=0.012） and C-PTGI score （β=0.622， P<0.01） were influencing factors of psychological capital among these parents， collectively explaining 57.6% of the total variability. ConclusionThe level of positive psychological capital among parents of children with leukemia warrants improvement. Factors including course of the children's illness， parental education level and post-traumatic growth significantly impacted their psychological capital.［Funded by Innovation and Entrepreneurship Project for Graduate Students of Xinjiang Medical University （number， CXCY2022047）］

Efficacy of psychological intervention on improving mental health status among patients with schizophrenia during rehabilitation in China： a Meta-analysis / 四川精神卫生

ObjectiveTo systematically evaluate the efficacy of psychological intervention on the mental health status of schizophrenia during rehabilitation in China， so as to provide references for the implementation of effective psychological intervention for patients. MethodsCochrane Library， PubMed， Web of Science， Chinese Biomedical Literature Database， CNKI， Wanfang Database and VIP Database were retrieved for the randomized controlled trials （RCTs） related to the psychological intervention for patients with schizophrenia during rehabilitation in China published from the inception to December 2021. After the assessment of risk of bias in literatures included， Meta-analysis was performed by using RevMan 5.4.1 software. ResultsA total of 1 211 subjects in 13 RCTs were enrolled， including 602 cases in the control group and 609 in the intervention group. Meta-analysis denoted that intervention group had lower scores of Symptom Checklist 90 （SCL-90） （WMD=-15.41， 95% CI：-18.67~-12.16， P<0.01）， Self-rating Depression Scale （SDS） （WMD=-9.07， 95% CI：-10.38~-7.77， P<0.01） and Self-rating Anxiety Scale （SAS） （WMD=-7.47， 95% CI：-9.85~-5.10， P<0.01） than those of control group after intervention， and the difference was statistically significant. ConclusionApplication of psychological intervention based on drug therapy has certain efficacy on improving mental health status in patients with schizophrenia during rehabilitation in China.

Research progress on stigma in family caregivers of patients with schizophrenia / 四川精神卫生

The purpose of this article is to reviews the research done on stigma in family caregivers of patients with schizophrenia， with a view to reducing stigma in the population and providing references for mental health workers to formulate relevant intervention measures. This paper conducted a review on the domestic and foreign literature on stigma in family caregivers of patients with schizophrenia， in which the relevant research progress was elaborated from four aspects： related concepts， assessment tools， influencing factors and intervention measures， and the existing limitations and directions for future research were summarized.

Association of related knowledge level and compliance of young and middle-aged hypertensive patients / 现代临床护理

Objective To evaluate the relevant knowledge level and compliance of young and middle-aged hypertensive patients,and explore the association of them. Method A total of 276 young and middle-aged hypertensive patients were surveyed using a hypertension knowledge level scale and treatment compliance questionnaire. Results The average score of young and middle-aged hypertensive patients on relevant knowledge was (62.55 ± 17.79). From different dimensions, the hypertensive patients got the highest score in the knowledge of their lifestyle,while they got the lowest score in their knowledge for complication.The average score of young and middle-aged hypertensive patients on treatment compliance was (71.53±9.87).From different dimensions,the hypertensive patients got the highest score in medication adherence,while they got the lowest score in exercise and pressure-relieving compliance.It showed that medication and drug compliance knowledge of middle-aged hypertensive patients was closely associated with treatment compliance(r=0.648, P<0.001)). Conclusions Both knowledge level and treatment compliance of young and middle-aged hypertensive patients should be improved.We should strengthen the population of knowledge about hypertension among young and middle-aged patients,especially the guidance of drug knowledge to improve their compliance.

Prevalence of dyslipidemia and the risk factors analysis of 39 980 subjects in Urumqi / 中华健康管理学杂志

Objective To analyze the prevalence of dyslipidemia and the risk factors of 39 980 subjects in Urumqi and to explore the characteristics of dyslipidemia's risk factors. Methods The following parameters of the subjects were determined: total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, blood sugar, and uric acid. The prevalence of dyslipidemia of different gender or age and risk factors for dyslipidemia were analyzed. Results Dyslipidemia total detection rate was 55.15%, the rate in male (66.03%) was significantly higher than in women (41.72%) (χ2=2 360.034, P<0.001);and in the men the various types of dyslipidemia detection rate was higher than those in the female, the TC (χ2=66.860, P<0.001) and TG (χ2=2 756.572, P<0.001), LDL-C (χ2=258.636, P<0.001), HDL-C (χ2=2 714.685, P<0.001) were significantly higher in men than in women; the detection rate of dyslipidemiaincreased with age, and then decreased gradually in the age group 50-59 years after the peak, the (high total cholesterol (χ2=2 529.462, P<0.001), hypertriglyceridemia (χ2=1 389.313, P<0.001) high LDL-C (χ2=1 552.074, P<0.001), low HDL-C (χ2=97.279, P<0.001) of all age groups the dyslipidemia detection rate differences were statistically significant. Risk factors of dyslipidemia: Logistic regression analyses showed that male gender (OR=1.681;95%CI:1.337-1.928), age (OR=1.299;95%CI:1.270-1.330), high diastolic blood pressure (OR=1.248;95%CI:1.145-1.361), high waist circumference(OR=1.895;95%CI:1.638-1.956), high uric acid(OR=1.200;95%CI:1.094-1.317), high blood glucose(OR=1.366;95%CI:1.229-1.517), high TG(OR=4.043;95%CI:3.770-4.335), high LDL-C(OR=40.148;95%CI:37.341-43.166), low HDL-C ( OR=1.982;95%CI:1.432-2.511) were closely correlated with the high TC; male ( OR=1.956;95%CI:1.853-2.066), high age(OR=1.060;95%CI:1.040-1.080), high BMI(OR=2.097;95%CI:1.968-2.235), high diastolic blood pressure(OR=1.512;95%CI:1.411-1.620), high waist circumference(OR=1.397;95%CI:1.313-1.478), high uric acid(OR=2.146;95%CI:1.995-2.308), high blood glucose(OR=1.498;95%CI:1.375-1.631), high TC(OR=4.030;95%CI:3.821-4.250), low HDL-C(OR=4.003;95%CI:3.764-4.258) were closely correlated with the high TG. Conclusion The prevalence of dyslipidemia is high in Urumqi area. Improving prevention knowledge, attention to life style, regular physical examination, abnormal condition in time, are important to prevent and reduce the occurrence of vascular diseases.

Epidemiological analysis of 5 577 cases of primary liver cancer in Xinjiang / 中华健康管理学杂志

Objective To analyze the clinical epidemiology of primary hepatocellular carcinoma (PHC) in the Xinjiang region. Methods Clinical data of the patients with PHC were collected at First Affiliated Hospital of Xinjiang Medical University from 5 577 cases from January 2002 to December 2014, their gender, race, age, household distribution, hepatitis virus-positive rate were analyzed retrospectively. Results Among the 5 577 eases, the men/women gender ratio was 3.45∶1;the proportion of Han, Uighur, Kazakh, and other ethnic groups (Hui, Mongolian, Manchu, Xibo) was 79.67%, 9.86%, 4.55%, 3.31%and 2.61%, respectively. The Constituent ratio difference between Uighur and Han was significant (P<0.05);4 232 patients had hepatitis B surface antigen (HBsAg) detection, and 3 833 patients had HCV antibody (HCV-Ab) detection. HBsAg was positive in 2 560 cases (60.49%), HCV-Ab was positive in 490 cases (12.78%). Hepatitis B virus detection positive rate in Uygur was 35.52%, in Kazak was 40.00%, which was lower than the Han's (65.68%, P<0.05). Urban and rural population had 3589 cases (64.35%) and 1988 cases (35.65%). Conclusion An increased risk for PHC was found in hepatitis virus-positive patients, the Xinjiang Uygur and Kazak people had significantly lower prevalence of HBV infection than the Han's. Appropriate measures should be taken for clinical diagnosis, treatment and prevention of PHC.

Amperometric Choline Biosensor Based on Dispersion of Multi-walled Carbon Nanotubes in Poly(diallyldimethylammonium chloride) via Layer-by-Layer Assembly Technique / 分析化学

Poly(diallyldimethylammonium chloride)(PDDA) was chosen to disperse multi-walled carbon nanotubes(MWCNTs) to prepare the stable PDDA-MWCNTs aqueous dispersion. Then, the positively charged PDDA-MWCNTs composite and negatively charged choline oxidase(ChOx) were employed to fabricate multilayer films on platinum(Pt) electrodes by layer-by-layer self-assembly technique, the anti-interferential film of Nafion was dropped at the end of the last multilayer films. The results showed that MWCNTs were evenly dispersed within the PDDA films and the multilayer films of (PDDA-MWCNTs)_n could improve the catalytic current response to choline significantly with the increased number of the multilayer films. The optimum assembly number was 6. The choline biosensor fabricated showed good linear correlation from 5×10~(-6)-2.5×10~(-4) mol/L with a detection limit of 2×10~(-6) mol/L(S/N=3), and the sensitivity was 21.97 mA/mol with a response time of 6.6 s, the RSD was less than 5%(n=3). Moreover, the biosensor exhibited an excellent anti-interferential property and a good stability.